I1 imidazoline receptors in cardiovascular regulation: the place of rilmenidine*1
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چکیده
منابع مشابه
the place of iranian public diplomacy in central asia
چکیده: نسبت به کارکرد و ماهیت دیپلماسی عمومی در جهان امروز نظریه های متعددی بیان گردیده و جایگاه آن در کنار نظریه های دیگر در محافل آکادمیک و دانشگاهی بررسی و تحلیل گردیده است. نظر به اهمیت دیپلماسی عمومی و جایگاه آن در سیاست خارجی ایران این نوشتار با تمرکز بر دیپلماسی عمومی در منطقه آسیای مرکزی تهیه و تنظیم شده است. این ضرورت از آنجا ناشی می شود که اولاً مفهوم دیپلماسی عمومی در سیاست خارجی ای...
15 صفحه اولPresynaptic I1-imidazoline receptors reduce GABAergic synaptic transmission in striatal medium spiny neurons.
Imidazoline receptors are expressed widely in the CNS. In the present study, whole-cell patch-clamp recordings were made from medium spiny neurons in dorsal striatum slices from the rat brain, and the roles of I1-imidazoline receptors in the modulation of synaptic transmission were studied. Moxonidine, an I1-imidazoline receptor agonist, decreased the GABAA receptor-mediated IPSCs in a concentr...
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1 The hypotensive effect of imidazoline-like drugs, such as clonidine, was attributed both to alpha2-adrenergic receptors and nonadrenergic imidazoline receptors, which are divided into I1, I2 and I3 subtypes. 2 We have recently synthesized a derivative of (2-(2-chloro-4-iodo-phenylamino)-5-methyl-pyrroline (LNP 911), the first high-affinity and selective ligand for I1 receptors (I1R), with a p...
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Symptoms of the metabolic syndrome (MetS), such as insulin resistance, obesity, and hypertension, have been associated with sympathetic hyperactivity. In addition, the adiponectin pathway has interesting therapeutic potentials in MetS. Our purpose was to investigate how targeting both the sympathetic nervous system and the adipose tissue (adiponectin secretion) with a drug selective for nonadre...
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The I(1)-imidazoline receptor is a novel target for drug development for hypertension and insulin resistance, major disorders associated with type 2 diabetes. In the present study, we examined the effects of a novel imidazoline agonist S43126, on phosphorylation of protein kinase B (PKB/Akt) and extracellular signal-regulated kinase (ERK1/2) in PC12 cells. We further examined the effects of S43...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2000
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(00)00224-7